AIDS vaccine first
نویسندگان
چکیده
منابع مشابه
First Steps toward a Globally Effective HIV/AIDS Vaccine
The enormous diversity of HIV-1 presents a formidable challenge for developing an effective AIDS vaccine. In this issue of Cell, Barouch et al. show that bioinformatically designed antigens, pieced together from multiple HIV immune epitopes, partially protect rhesus macaques from simian-human immunodeficiency virus infection. This "mosaic" approach holds promise for the development of broadly p...
متن کاملProspects for an AIDS vaccine.
Acquired immunodeficiency syndrome (AIDS) was first identified at the end of 1981.1 In 1983, the causative virus, human immunodeficiency virus (HIV-1), was identified2, almost certainly having entered humans from a reservoir in chimpanzees, possibly on several occasions.3 Since 1981 the virus has spread to cause possibly the most serious epidemic infection in human history. The virus has divers...
متن کاملThe first measles vaccine.
Like in the more familiar story of polio vaccine, the development of the first successful live attenuated vaccine against measles began in the laboratory of John Enders. One of the greatest virologists of the 20th century, Enders pioneered the technique of viral tissue culture, which makes it possible to growviruses in vitro in cells nourished in laboratory media.1 In 1949, he and his pediatric...
متن کاملThe Development of an AIDS Mucosal Vaccine
It is well known that mucosal tissues contain the largest surface area of the human body and are the front line of natural host defense against various pathogens. In fact, more than 80% of infectious disease pathogens probably gain entry into the susceptible human hosts through open mucosal surfaces. Human immunodeficiency virus type one (HIV-1), a mainly sexually transmitted virus, also primar...
متن کاملEngineered Listeria monocytogenes as an AIDS vaccine.
Listeria monocytogenes (Lm) is an attractive vector to elicit T cell immunity because it infects antigen-presenting cells and because infection originates at the mucosa. Lm expressing HIV gag elicits sustained high levels of gag-specific CTL in mice. Since Lm causes disease in immunocompromised hosts, a highly attenuated strain of Lm that requires D-Ala for viability was produced. Attenuated ba...
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ژورنال
عنوان ژورنال: Nature
سال: 1988
ISSN: 0028-0836,1476-4687
DOI: 10.1038/333005f0